ASZ1

Across TCGA patient cohorts, ASZ1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASZ1-associated genes across cancer lineages are Akt_pT308, ASNS, and PCNA. Each is linked with ASZ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASZ1-to-partner and partner-to-ASZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by ASZ1-low versus ASZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASZ1→partner) and Y-score (partner→ASZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.531	+1.906	.036	.016	3	3
UCEC	ASNS →	+0.656	+3.700	<.001	.001	3	2
UCEC	PCNA →	+0.273	+3.169	.001	.018	3	2
UCEC	Rab11 →	-0.136	-2.415	.020	.003	3	2
UCEC	ATM →	-0.593	-1.906	.001	.016	3	2
UCEC	Caspase-8 →	-0.274	-3.780	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Akt_pT308 by ASZ1 expression — UCEC

Explore this box plot interactively →