ASZ1

Across TCGA pan-cancer cohorts, ASZ1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ASZ1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ASZ1 RNA is repressed in tumor relative to normal tissue. In most cancer types ASZ1 is over-expressed in tumor, although a few such as LUSC and PAAD show the opposite, repressed pattern.

LUSC, KICH, and BRCA are the cancer types where ASZ1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASZ1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	III,IV	−0.226	<.001	8	view →
KICH	All	All	+0.104	.001	6	view →
BRCA	Female	II,III,IV	+0.053	.009	4	view →
UCEC	All	II,III,IV	+0.023	.028	4	view →
PAAD	All	All	−0.067	.011	2	view →
KIRC	Female	II,III,IV	−0.013	.008	2	view →
COAD	All	II,III,IV	+0.007	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ASZ1–LUSC

Open the LUSC breakdown →