ASXL3

Across TCGA patient cohorts, ASXL3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,570 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ASXL3-associated proteins across cancer lineages are RFX3_S155, NBEA, and NOVA2. Each is linked with ASXL3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ASXL3-to-partner and partner-to-ASXL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ASXL3 versus RFX3_S155 in HNSC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ASXL3→partner) and Y-score (partner→ASXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RFX3_S155 →	+0.625	+0.736	<.001	.002	3	5
UCEC	NBEA →	+0.502	+0.597	<.001	<.001	3	5
PDAC	NOVA2 →	+0.730	+0.616	<.001	<.001	3	5
PDAC	NES_S1590 →	+1.398	+0.441	.004	.002	3	4
PDAC	NSDHL →	-0.376	-0.477	<.001	<.001	3	4
LSCC	PKIG →	+0.461	+0.376	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,570 associations by consensus.

ASXL3 vs RFX3_S155 — HNSC

Explore this scatter interactively →