ASXL3

Across TCGA pan-cancer cohorts, ASXL3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ASXL3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ASXL3 RNA is repressed in tumor relative to normal tissue. In most cancer types ASXL3 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and BLCA are the cancer types where ASXL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASXL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.895	<.001	12	view →
THCA	Male	All	−1.717	<.001	11	view →
BLCA	Male	IV	−1.287	.001	10	view →
UCEC	All	III,IV	−1.217	<.001	8	view →
STAD	All	All	−0.300	.001	6	view →
READ	All	All	−0.622	<.001	5	view →
KICH	Female	III,IV	−0.729	.008	4	view →
BRCA	All	All	−0.451	<.001	4	view →
KIRC	All	II,III,IV	−0.281	.009	4	view →
KIRP	All	All	−0.361	.021	3	view →
LUSC	All	II,III,IV	−0.187	.008	3	view →
PRAD	All	All	−0.340	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ASXL3–COAD

Open the COAD breakdown →