ASXL3

Across TCGA cell cohorts, ASXL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,839 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ASXL3-associated GO terms across cancer lineages are Extracellular matrix organization, External encapsulating structure organization, and Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. Each is linked with ASXL3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ASXL3-to-partner and partner-to-ASXL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Extracellular matrix organization grouped by ASXL3-low versus ASXL3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASXL3→partner) and Y-score (partner→ASXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Extracellular matrix organization →	-0.132	-0.385	.009	.004	3	6
BONE	External encapsulating structure organization →	-0.134	-0.386	.008	.004	3	6
SOFT_TISSUE	Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell →	-1.288	-0.760	<.001	.001	3	6
SOFT_TISSUE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.150	+0.624	<.001	<.001	3	5
CNS	Regulation of actin filament polymerization →	-0.040	-0.375	.009	.009	3	5
LUNG_SCLC	Fibrinolysis →	-0.676	-1.230	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,839 associations by consensus.

Extracellular matrix organization by ASXL3 expression — BONE

Explore this box plot interactively →