ASXL3

Across TCGA cell cohorts, ASXL3 mutation is significantly associated with the RNA expression of many other genes, with 1,005 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASXL3-associated genes across cancer lineages are DNAAF3, KRTAP7-1, and PRAC1. Each is linked with ASXL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASXL3-to-partner and partner-to-ASXL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAAF3 grouped by ASXL3-low versus ASXL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASXL3→partner) and Y-score (partner→ASXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNAAF3 →	+1.026	+1.906	<.001	.001	3	3
OESOPHAGUS	KRTAP7-1 →	+0.085	+3.273	<.001	.004	3	2
SOFT_TISSUE	PRAC1 →	+3.139	+3.748	<.001	.004	3	2
LUNG_NSCLC_LUSC	VSTM2B →	+0.068	+2.544	.006	.003	3	2
LARGE_INTESTINE	IFT27 →	+0.615	+1.491	.004	.002	3	2
LARGE_INTESTINE	DESI1 →	+0.451	+2.000	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,005 associations by consensus.

DNAAF3 by ASXL3 expression — LARGE_INTESTINE

Explore this box plot interactively →