ASXL1

Across TCGA patient cohorts, ASXL1 mutation is significantly associated with the RNA expression of many other genes, with 5,645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASXL1-associated genes across cancer lineages are INTS9, ERI1, and RPS6KA1. Each is linked with ASXL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ASXL1-to-partner and partner-to-ASXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INTS9 grouped by ASXL1-low versus ASXL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASXL1→partner) and Y-score (partner→ASXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INTS9 →	+0.341	+2.271	.001	<.001	3	4
UCEC	ERI1 →	+0.504	+2.413	<.001	<.001	3	4
UCEC	RPS6KA1 →	+0.344	+2.082	<.001	<.001	3	4
UCEC	GTF2E2 →	+0.384	+1.595	<.001	<.001	3	4
COAD	KRTAP20-4 →	+0.155	+4.345	<.001	.003	3	3
COAD	ETDB →	+0.055	+2.887	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,645 associations by consensus.

INTS9 by ASXL1 expression — UCEC

Explore this box plot interactively →