ASTN2

Across TCGA patient cohorts, ASTN2 mutation is significantly associated with the RNA expression of many other genes, with 8,166 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASTN2-associated genes across cancer lineages are MELK, RRM2, and MTHFD2. Each is linked with ASTN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ASTN2-to-partner and partner-to-ASTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MELK grouped by ASTN2-low versus ASTN2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTN2→partner) and Y-score (partner→ASTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MELK →	+0.703	+1.937	<.001	.002	3	6
UCEC	RRM2 →	+0.702	+2.284	<.001	<.001	3	6
STAD	MTHFD2 →	+0.516	+3.347	.004	.004	3	6
STAD	ANP32E →	+0.531	+3.476	.001	.002	3	6
STAD	NCAPG2 →	+0.601	+3.496	.002	.002	3	6
UCEC	PAXIP1 →	+0.342	+1.550	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,166 associations by consensus.

MELK by ASTN2 expression — LUAD

Explore this box plot interactively →