ASTN2

Across TCGA pan-cancer cohorts, ASTN2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ASTN2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ASTN2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ASTN2 is over-expressed in tumor, although a few such as UCEC and COAD show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where ASTN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASTN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+1.071	<.001	10	view →
LIHC	All	II,III,IV	+0.763	<.001	9	view →
KICH	Female	All	+1.846	<.001	7	view →
PRAD	All	All	+0.820	<.001	2	view →
BRCA	All	III,IV	+0.724	.016	2	view →
LUSC	All	All	+0.618	.007	2	view →
CHOL	All	All	+0.593	<.001	2	view →
UCEC	All	All	−0.492	.036	2	view →
COAD	All	II,III,IV	−0.271	.006	2	view →
ESCA	All	All	−0.956	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ASTN2–HNSC

Open the HNSC breakdown →