ASTN2

Across TCGA patient cohorts, ASTN2 mutation is significantly associated with the total protein of many other genes, with 92 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ASTN2-associated genes across cancer lineages are 4E-BP1, FoxM1, and Cyclin-B1. Each is linked with ASTN2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ASTN2-to-partner and partner-to-ASTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ASTN2-low versus ASTN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTN2→partner) and Y-score (partner→ASTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.215	+2.502	.003	.001	3	5
STAD	FoxM1 →	+0.457	+3.321	<.001	.008	3	4
UCEC	Cyclin-B1 →	+0.489	+2.247	.001	.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.179	+2.423	<.001	.001	3	4
COAD	JNK2 →	-0.185	-1.898	.005	.016	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.245	-1.222	.045	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

4E-BP1 by ASTN2 expression — UCEC

Explore this box plot interactively →