ASTN2

Across TCGA cell cohorts, ASTN2 mutation is significantly associated with the RNA expression of many other genes, with 821 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASTN2-associated genes across cancer lineages are THUMPD3, HPF1, and PDE6C. Each is linked with ASTN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASTN2-to-partner and partner-to-ASTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THUMPD3 grouped by ASTN2-low versus ASTN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTN2→partner) and Y-score (partner→ASTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	THUMPD3 →	+0.381	+3.169	.004	.005	3	3
LARGE_INTESTINE	HPF1 →	+0.514	+2.011	.007	.007	3	3
LARGE_INTESTINE	PDE6C →	+0.171	+2.717	.001	<.001	3	3
BLOOD_Leukemia	TSHB →	+0.186	+4.013	<.001	<.001	3	2
BLOOD_Leukemia	ZIC5 →	+0.464	+3.474	.005	.007	3	2
LARGE_INTESTINE	FBXW10 →	+0.146	+1.906	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 821 associations by consensus.

THUMPD3 by ASTN2 expression — LARGE_INTESTINE

Explore this box plot interactively →