ASTN1

Across TCGA cell cohorts, ASTN1 mutation is significantly associated with the RNA expression of many other genes, with 132 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASTN1-associated genes across cancer lineages are C2orf80, BSX, and KRTAP2-4. Each is linked with ASTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASTN1-to-partner and partner-to-ASTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf80 grouped by ASTN1-low versus ASTN1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTN1→partner) and Y-score (partner→ASTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	C2orf80 →	+0.058	+3.392	.001	.007	3	2
OVARY	BSX →	+0.078	+4.029	<.001	.009	3	2
OVARY	KRTAP2-4 →	+0.112	+4.990	<.001	.001	3	2
LARGE_INTESTINE	BMP7 →	-1.867	-2.541	.006	.005	3	2
LARGE_INTESTINE	MED30 →	+0.499	+3.082	.004	.007	3	2
UPPER_AERODIGESTIVE_TRACT	ACTRT1 →	+0.059	+3.870	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 132 associations by consensus.

C2orf80 by ASTN1 expression — OESOPHAGUS

Explore this box plot interactively →