ASTE1

Across TCGA patient cohorts, ASTE1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASTE1-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and C-Raf. Each is linked with ASTE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASTE1-to-partner and partner-to-ASTE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ASTE1-low versus ASTE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTE1→partner) and Y-score (partner→ASTE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.381	+2.137	.002	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.445	+2.019	.027	.005	3	2
UCEC	C-Raf →	+0.131	+1.247	.007	.045	3	2
UCEC	EGFR_pY1068 →	-0.218	-2.115	.010	.016	3	1
UCEC	EGFR →	-0.126	-2.000	.021	.030	3	1
UCEC	eIF4E →	+0.156	+2.472	.030	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

MEK1 by ASTE1 expression — UCEC

Explore this box plot interactively →