ASTE1

Across TCGA cell cohorts, ASTE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,373 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASTE1-associated GO terms across cancer lineages are Double-strand break repair via nonhomologous end joining, Negative regulation of cell cycle G2/M phase transition, and Double-strand break repair via homologous recombination. Each is linked with ASTE1 in more than 17 cancer types. Because this analysis shows association rather than direction, both ASTE1-to-partner and partner-to-ASTE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via nonhomologous end joining grouped by ASTE1-low versus ASTE1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTE1→partner) and Y-score (partner→ASTE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.072	+0.706	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle G2/M phase transition →	+0.095	+0.825	.001	<.001	3	15
PANCREAS	Double-strand break repair via homologous recombination →	+0.077	+0.606	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Mitotic G2/M transition checkpoint →	+0.107	+0.711	.001	.002	3	14
PANCREAS	Double-strand break repair →	+0.063	+0.676	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of G2/M transition of mitotic cell cycle →	+0.097	+0.721	.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,373 associations by consensus.

Double-strand break repair via nonhomologous end joining by ASTE1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →