ASTE1

Across TCGA cell cohorts, ASTE1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASTE1-associated genes across cancer lineages are REG1B, HTR3D, and OR5D14. Each is linked with ASTE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASTE1-to-partner and partner-to-ASTE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by ASTE1-low versus ASTE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTE1→partner) and Y-score (partner→ASTE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.565	+3.781	<.001	<.001	3	2
BLOOD_Leukemia	HTR3D →	+0.014	+4.539	<.001	.007	3	2
OESOPHAGUS	OR5D14 →	+0.033	+4.906	<.001	.006	3	1
OESOPHAGUS	ACSM2B →	+0.080	+4.906	<.001	.006	3	1
LARGE_INTESTINE	REG3A →	+2.116	+3.502	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

REG1B by ASTE1 expression — LARGE_INTESTINE

Explore this box plot interactively →