ASPHD1

Across TCGA cell cohorts, ASPHD1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASPHD1-associated genes across cancer lineages are CDH20, AGRP, and MS4A7. Each is linked with ASPHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPHD1-to-partner and partner-to-ASPHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH20 grouped by ASPHD1-low versus ASPHD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPHD1→partner) and Y-score (partner→ASPHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH20 →	+0.131	+3.766	<.001	.004	3	1
LARGE_INTESTINE	AGRP →	+0.150	+3.994	<.001	.002	3	1
LARGE_INTESTINE	MS4A7 →	+0.034	+3.679	.006	.005	3	1
LARGE_INTESTINE	OR2C1 →	+0.103	+3.578	.002	.006	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1
LARGE_INTESTINE	SNTG2 →	+0.156	+3.789	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

CDH20 by ASPHD1 expression — LARGE_INTESTINE

Explore this box plot interactively →