Across TCGA patient cohorts, ASPH mutation is significantly associated with the RNA expression of many other genes, with 4,410 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPH-associated genes across cancer lineages are PSMB6, CHAF1A, and RAC3. Each is linked with ASPH in more than 3 cancer types. Because this analysis shows association rather than direction, both ASPH-to-partner and partner-to-ASPH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPH→partner) and Y-score (partner→ASPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMB6 →	+0.443	+3.392	<.001	<.001	3	4
UCEC	CHAF1A →	+0.667	+2.065	<.001	<.001	3	4
HNSC	RAC3 →	+1.217	+3.471	.002	.002	3	4
UCEC	TIMM22 →	+0.485	+2.597	<.001	<.001	3	4
READ	LINC01090 →	+0.087	+4.860	<.001	<.001	3	4
UCEC	CBARP →	+0.665	+1.830	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,410 associations by consensus.

Exploration

ASPH survival (RNA) · tumor vs normal (RNA) · all ASPH data types