Across TCGA pan-cancer cohorts, ASPH RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ASPH’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ASPH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ASPH is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.
KIRC, THCA, and HNSC are the cancer types where ASPH tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASPH RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.