Across TCGA cell cohorts, ASPH mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ASPH-associated genes across cancer lineages are OR8K3, PIP, and RGSL1. Each is linked with ASPH in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPH-to-partner and partner-to-ASPH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPH→partner) and Y-score (partner→ASPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR8K3 →	+0.007	+4.169	<.001	.008	3	2
BLOOD_Myeloma	PIP →	+0.040	+4.807	<.001	.006	3	1
SKIN	RGSL1 →	+0.015	+4.977	.002	.007	3	1
SKIN	KRTAP21-1 →	+0.050	+6.022	<.001	.001	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1
OVARY	C12orf40 →	+0.010	+4.444	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

ASPH survival (RNA) · tumor vs normal (RNA) · all ASPH data types