ASPG

Across TCGA patient cohorts, ASPG mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPG-associated genes across cancer lineages are ERK2, CD31, and Cyclin-B1. Each is linked with ASPG in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPG-to-partner and partner-to-ASPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ASPG-low versus ASPG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPG→partner) and Y-score (partner→ASPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.283	+1.906	<.001	.015	3	2
UCEC	CD31 →	-0.119	-2.311	.034	.034	3	2
UCEC	Cyclin-B1 →	+0.671	+3.584	.001	.002	3	2
UCEC	DJ-1 →	+0.170	+3.183	.007	.009	3	2
UCEC	14-3-3_beta →	-0.099	-3.295	.010	.009	3	1
UCEC	EGFR_pY1068 →	-0.333	-3.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ERK2 by ASPG expression — UCEC

Explore this box plot interactively →