ASPG

Across TCGA pan-cancer cohorts, ASPG RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ASPG’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ASPG RNA is repressed in tumor relative to normal tissue. In most cancer types ASPG is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KIRP are the cancer types where ASPG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASPG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−1.970	<.001	11	view →
THCA	Female	II,III,IV	−1.053	<.001	11	view →
KIRP	Female	II,III,IV	−3.496	<.001	9	view →
HNSC	All	II,III,IV	−0.999	.001	9	view →
LIHC	Male	II,III,IV	−3.272	<.001	8	view →
LUAD	Female	III,IV	−1.618	<.001	7	view →
KICH	All	All	−1.242	.001	7	view →
UCEC	All	All	−1.095	<.001	6	view →
BRCA	All	III,IV	−0.246	.006	4	view →
CHOL	Female	All	−4.903	<.001	3	view →
LUSC	Female	All	−0.915	.015	2	view →
STAD	All	II,III,IV	−0.676	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ASPG–COAD

Open the COAD breakdown →