ASPG

Across TCGA cell cohorts, ASPG RNA expression is significantly associated with the go_rna of many other GO terms, with 1,296 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ASPG-associated GO terms across cancer lineages are Regulation of CD8-positive, alpha-beta T cell differentiation, Negative regulation of ubiquitin-dependent protein catabolic process, and Negative regulation of RNA catabolic process. Each is linked with ASPG in more than 5 cancer types. Because this analysis shows association rather than direction, both ASPG-to-partner and partner-to-ASPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of CD8-positive, alpha-beta T cell differentiation grouped by ASPG-low versus ASPG-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPG→partner) and Y-score (partner→ASPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of CD8-positive, alpha-beta T cell differentiation →	+0.122	+0.376	<.001	.003	3	6
BLOOD_Lymphoma	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.046	+0.319	.001	.009	3	5
OVARY	Negative regulation of RNA catabolic process →	+0.053	+0.386	<.001	<.001	2	6
OVARY	Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway →	+0.134	+0.386	.001	.001	3	4
PANCREAS	Regulation of myoblast fusion →	+0.082	+0.272	<.001	.005	3	4
BLOOD_Lymphoma	Positive regulation of protein depolymerization →	-0.085	-0.357	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,296 associations by consensus.

Regulation of CD8-positive, alpha-beta T cell differentiation by ASPG expression — LARGE_INTESTINE

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