ASPG

Across TCGA cell cohorts, ASPG mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASPG-associated genes across cancer lineages are OR13H1, C5orf52, and GRIFIN. Each is linked with ASPG in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPG-to-partner and partner-to-ASPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13H1 grouped by ASPG-low versus ASPG-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPG→partner) and Y-score (partner→ASPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR13H1 →	+0.070	+4.977	<.001	.007	3	1
SKIN	C5orf52 →	+0.041	+5.415	<.001	.004	3	1
SKIN	GRIFIN →	+0.040	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	GYPB →	+0.185	+4.544	<.001	.003	3	1
LARGE_INTESTINE	ZP2 →	+0.131	+4.000	.001	.002	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR13H1 by ASPG expression — SKIN

Explore this box plot interactively →