ASPA

Across TCGA patient cohorts, ASPA mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPA-associated genes across cancer lineages are EGFR_pY1068, Acetyl-a-Tubulin-Lys40, and JNK_pT183_Y185. Each is linked with ASPA in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPA-to-partner and partner-to-ASPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ASPA-low versus ASPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPA→partner) and Y-score (partner→ASPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.195	-2.000	.047	.010	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.600	+2.594	.002	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.146	-2.321	.027	.034	3	1
UCEC	JNK2 →	+0.210	+1.584	.007	.036	3	1
UCEC	MEK1 →	+0.565	+3.169	<.001	<.001	3	1
UCEC	mTOR_pS2448 →	-0.132	-2.308	.023	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by ASPA expression — UCEC

Explore this box plot interactively →