ASMTL-AS1

Across TCGA pan-cancer cohorts, ASMTL-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated ASMTL-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ASMTL-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ASMTL-AS1 expression acts as an unfavorable survival marker, although some lineages such as STAD and BLCA show a favorable association.

KIRC, COAD, and STAD are the cancer types where ASMTL-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.467	0.693	<.001	110	view →
COAD	OS	Quartile	III,IV	0.580	0.966	<.001	74	view →
STAD	OS	Median	II,III,IV	0.741	0.428	.001	60	view →
BLCA	OS	Quartile	II,III,IV	0.731	0.490	<.001	51	view →
SKCM	OS	Median	III,IV	0.472	0.294	.005	28	view →
READ	OS	Median	III,IV	0.674	0.282	.010	20	view →
LGG	DFS	Median	All	0.289	0.456	<.001	19	view →
MESO	OS	Median	All	0.315	0.655	.020	18	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	18	view →
PRAD	DFS	Median	All	0.827	0.936	<.001	18	view →
THYM	DFS	Quartile	All	1.000	0.620	.010	13	view →
PAAD	OS	Quartile	All	0.584	0.316	.025	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

ASMTL-AS1–KIRC (DFS)

Open the KIRC breakdown →