ASL

Across TCGA patient cohorts, ASL protein abundance is significantly associated with the RNA expression of many other genes, with 17,896 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ASL-associated genes across cancer lineages are PDZK1IP1, CBX1, and SLC22A18. Each is linked with ASL in more than 6 cancer types. Because this analysis shows association rather than direction, both ASL-to-partner and partner-to-ASL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ASL versus PDZK1IP1 in OV, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASL→partner) and Y-score (partner→ASL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDZK1IP1 →	+2.396	+0.457	<.001	.001	3	7
LSCC	CBX1 →	-0.624	-0.295	<.001	<.001	3	6
CCRCC	SLC22A18 →	+0.694	+0.394	<.001	<.001	3	6
OV	GSTK1 →	+0.659	+0.464	.001	.006	3	6
BRCA	TTC39A →	+0.921	+0.413	.001	<.001	3	6
UCEC	HROB →	-0.936	-0.346	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,896 associations by consensus.

ASL vs PDZK1IP1 — OV

Explore this scatter interactively →