ASL

Across TCGA pan-cancer cohorts, ASL RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ASL data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ASL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ASL expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

CESC, UVM, and MESO are the cancer types where ASL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.657	0.827	<.001	112	view →
UVM	OS	Median	III,IV	0.617	0.947	<.001	108	view →
MESO	OS	Quartile	All	0.222	0.486	.002	71	view →
ACC	DFS	Tertile	All	0.332	0.807	<.001	69	view →
LGG	DFS	Median	All	0.641	0.828	<.001	51	view →
LUSC	OS	Tertile	All	0.574	0.764	<.001	50	view →
OV	OS	Median	All	0.808	0.872	.008	48	view →
READ	DFS	Median	All	0.876	0.398	.003	32	view →
KIRC	DFS	Median	All	0.743	0.507	.001	25	view →
SCLC	DFS	Tertile	II,III,IV	0.207	0.503	.014	16	view →
ESCA	OS	Median	All	0.563	1.000	.003	15	view →
PAAD	OS	Median	All	0.486	0.700	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ASL–CESC (DFS)

Open the CESC breakdown →