ASL

Across TCGA patient cohorts, ASL mutation is significantly associated with the RNA expression of many other genes, with 1,117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASL-associated genes across cancer lineages are NUFIP1, KIAA1958, and KLC2. Each is linked with ASL in more than 2 cancer types. Because this analysis shows association rather than direction, both ASL-to-partner and partner-to-ASL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUFIP1 grouped by ASL-low versus ASL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASL→partner) and Y-score (partner→ASL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUFIP1 →	+0.411	+3.234	.009	.008	3	3
SKCM	KIAA1958 →	+0.571	+3.591	.002	.001	3	2
SKCM	KLC2 →	+0.657	+3.591	.002	.001	3	2
SKCM	LINC01758 →	+0.379	+2.770	<.001	.002	3	2
BLCA	RNU6-795P →	+0.377	+2.580	.009	.009	3	2
LUAD	SSXP1 →	+0.329	+6.444	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,117 associations by consensus.

NUFIP1 by ASL expression — UCEC

Explore this box plot interactively →