ASL

Across TCGA patient cohorts, ASL mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASL-associated genes across cancer lineages are PTEN, EGFR_pY1068, and eIF4E. Each is linked with ASL in more than 1 cancer types. Because this analysis shows association rather than direction, both ASL-to-partner and partner-to-ASL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTEN grouped by ASL-low versus ASL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASL→partner) and Y-score (partner→ASL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PTEN →	+0.442	+3.000	.046	.036	3	1
UCEC	EGFR_pY1068 →	-0.271	-2.321	.013	.034	3	1
UCEC	eIF4E →	+0.250	+2.807	.006	.003	3	1
UCEC	A-Raf_pS299 →	-0.222	-2.807	<.001	.003	3	1
UCEC	Heregulin →	-0.171	-2.459	.001	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.225	-3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PTEN by ASL expression — SKCM

Explore this box plot interactively →