ASL

Across TCGA cell cohorts, ASL RNA expression is significantly associated with the go_rna of many other GO terms, with 5,092 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ASL-associated GO terms across cancer lineages are L-arginine biosynthetic process, Chromosomal 5-methylcytosine DNA demethylation pathway, and Endocytic recycling. Each is linked with ASL in more than 10 cancer types. Because this analysis shows association rather than direction, both ASL-to-partner and partner-to-ASL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-arginine biosynthetic process grouped by ASL-low versus ASL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASL→partner) and Y-score (partner→ASL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	L-arginine biosynthetic process →	+0.539	+1.028	.005	.003	3	11
STOMACH	Chromosomal 5-methylcytosine DNA demethylation pathway →	-0.218	-0.945	<.001	.001	3	11
BONE	Endocytic recycling →	+0.061	+1.159	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Regulation of antigen processing and presentation →	+0.198	+1.167	<.001	.003	3	10
LUNG_NSCLC_LUSC	Negative regulation of small GTPase mediated signal transduction →	+0.088	+0.924	<.001	<.001	3	10
BONE	Regulation of protein localization to plasma membrane →	+0.127	+1.743	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,092 associations by consensus.

L-arginine biosynthetic process by ASL expression — BONE

Explore this box plot interactively →