ASL

Across TCGA cell cohorts, ASL mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASL-associated genes across cancer lineages are MYOD1, NKX2-6, and TLE7. Each is linked with ASL in more than 1 cancer types. Because this analysis shows association rather than direction, both ASL-to-partner and partner-to-ASL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by ASL-low versus ASL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASL→partner) and Y-score (partner→ASL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	C6orf118 →	+0.145	+4.115	<.001	.001	3	1
LARGE_INTESTINE	ITGAD →	+0.015	+3.510	<.001	.003	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MYOD1 by ASL expression — BLOOD_Leukemia

Explore this box plot interactively →