ASIC5

Across TCGA patient cohorts, ASIC5 mutation is significantly associated with the RNA expression of many other genes, with 2,908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASIC5-associated genes across cancer lineages are MIR3137, MIR3170, and TSPY16P. Each is linked with ASIC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASIC5-to-partner and partner-to-ASIC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3137 grouped by ASIC5-low versus ASIC5-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC5→partner) and Y-score (partner→ASIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MIR3137 →	+0.545	+5.352	<.001	.005	3	3
HNSC	MIR3170 →	+0.477	+5.182	<.001	.007	3	3
UCEC	TSPY16P →	+0.022	+4.606	<.001	.001	3	3
LUAD	MIR4716 →	+0.334	+4.798	<.001	<.001	3	3
LUSC	MIR3648-2 →	+0.122	+4.424	<.001	.004	3	3
READ	IGHD5-12 →	+1.742	+5.421	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,908 associations by consensus.

MIR3137 by ASIC5 expression — GBM

Explore this box plot interactively →