ASIC5

Across TCGA pan-cancer cohorts, ASIC5 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ASIC5 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ASIC5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ASIC5 expression acts as an unfavorable survival marker, although some lineages such as LUSC and SKCM show a favorable association.

KIRP, KIRC, and MESO are the cancer types where ASIC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.244	0.670	<.001	129	view →
KIRC	OS	Tertile	All	0.505	0.669	<.001	118	view →
MESO	OS	Tertile	All	0.247	0.431	.002	90	view →
GBM	OS	Median	All	0.309	0.484	<.001	45	view →
LGG	OS	Tertile	All	0.336	0.498	<.001	38	view →
CHOL	OS	Quartile	II,III,IV	0.066	0.757	<.001	36	view →
LUAD	DFS	Quartile	III,IV	0.245	0.651	.002	36	view →
CESC	OS	Tertile	IV	0.167	0.612	.008	36	view →
ACC	OS	Tertile	All	0.122	0.752	<.001	36	view →
KICH	OS	Quartile	II,III,IV	0.849	1.000	.009	32	view →
LUSC	DFS	Quartile	II,III,IV	0.883	0.293	<.001	26	view →
UCEC	DFS	Tertile	All	0.522	0.662	.004	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ASIC5–KIRP (DFS)

Open the KIRP breakdown →