ASIC5

Across TCGA patient cohorts, ASIC5 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASIC5-associated genes across cancer lineages are ATM, PCNA, and TFRC. Each is linked with ASIC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASIC5-to-partner and partner-to-ASIC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ASIC5-low versus ASIC5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC5→partner) and Y-score (partner→ASIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.782	-3.000	<.001	.035	3	2
UCEC	PCNA →	+0.282	+2.415	.001	.003	3	2
UCEC	TFRC →	+0.529	+1.906	.013	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.791	+1.720	<.001	.025	3	2
UCEC	4E-BP1 →	+0.354	+2.415	.001	.003	3	2
COAD	PTEN →	-0.170	-2.991	.019	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by ASIC5 expression — COAD

Explore this box plot interactively →