ASIC5

Across TCGA cell cohorts, ASIC5 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ASIC5-associated genes across cancer lineages are ST8SIA3, OR4S1, and CLEC4C. Each is linked with ASIC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASIC5-to-partner and partner-to-ASIC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ST8SIA3 grouped by ASIC5-low versus ASIC5-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC5→partner) and Y-score (partner→ASIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ST8SIA3 →	+0.039	+4.199	<.001	.007	3	1
LUNG_SCLC	OR4S1 →	+0.026	+5.643	<.001	.002	3	1
LUNG_SCLC	CLEC4C →	+0.047	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	OXT →	+0.044	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	NXNL1 →	+0.031	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	SPAG11A →	+0.049	+4.452	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ST8SIA3 by ASIC5 expression — BREAST

Explore this box plot interactively →