ASIC4

Across TCGA patient cohorts, ASIC4 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASIC4-associated genes across cancer lineages are MEK1, ATM, and eEF2. Each is linked with ASIC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASIC4-to-partner and partner-to-ASIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ASIC4-low versus ASIC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC4→partner) and Y-score (partner→ASIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.397	+2.392	<.001	<.001	3	3
UCEC	ATM →	-0.626	-1.893	<.001	<.001	3	3
UCEC	eEF2 →	+0.293	+1.201	.008	.028	3	3
UCEC	GAPDH →	+0.404	+2.222	.015	.009	3	3
UCEC	JNK2 →	+0.188	+1.201	.002	.028	3	3
UCEC	Shc_pY317 →	-0.179	-1.893	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

MEK1 by ASIC4 expression — UCEC

Explore this box plot interactively →