ASIC4

Across TCGA cell cohorts, ASIC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,168 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASIC4-associated GO terms across cancer lineages are Cytoplasmic translation, Calcium-independent cell-matrix adhesion, and Regulation of macroautophagy. Each is linked with ASIC4 in more than 9 cancer types. Because this analysis shows association rather than direction, both ASIC4-to-partner and partner-to-ASIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic translation grouped by ASIC4-low versus ASIC4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC4→partner) and Y-score (partner→ASIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Cytoplasmic translation →	+0.064	+0.190	.007	.009	3	10
UPPER_AERODIGESTIVE_TRACT	Calcium-independent cell-matrix adhesion →	+0.171	+0.163	.001	.007	3	9
LIVER	Regulation of macroautophagy →	+0.060	+0.174	.003	.004	2	10
OESOPHAGUS	Protein polyglycylation →	+1.443	+0.468	<.001	.006	3	8
UPPER_AERODIGESTIVE_TRACT	Viral transcription →	+0.128	+0.138	<.001	.008	3	8
BONE	5S class rRNA transcription by RNA polymerase III →	+0.129	+0.938	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,168 associations by consensus.

Cytoplasmic translation by ASIC4 expression — OVARY

Explore this box plot interactively →