ASIC4

Across TCGA cell cohorts, ASIC4 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASIC4-associated genes across cancer lineages are PDE4C, SPCS1, and TNP1. Each is linked with ASIC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASIC4-to-partner and partner-to-ASIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE4C grouped by ASIC4-low versus ASIC4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC4→partner) and Y-score (partner→ASIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDE4C →	+0.691	+3.451	.001	.002	3	1
LARGE_INTESTINE	SPCS1 →	+0.357	+3.364	.009	.002	3	1
LARGE_INTESTINE	TNP1 →	+0.071	+3.000	<.001	.003	3	1
LARGE_INTESTINE	PDS5A →	+0.606	+3.364	.001	.002	3	1
LARGE_INTESTINE	MTX2 →	+0.349	+3.364	.003	.002	3	1
LARGE_INTESTINE	TPRG1L →	+0.721	+3.067	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

PDE4C by ASIC4 expression — LARGE_INTESTINE

Explore this box plot interactively →