Across TCGA pan-cancer cohorts, ASIC4-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ASIC4-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ASIC4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ASIC4-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

KIRP, MESO, and LGG are the cancer types where ASIC4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.778	0.920	<.001	82	view →
MESO	DFS	Quartile	III,IV	0.253	0.547	.001	72	view →
LGG	OS	Median	All	0.904	0.707	<.001	54	view →
UCS	DFS	Median	II,III,IV	0.554	0.156	.003	36	view →
BLCA	DFS	Tertile	IV	0.124	0.279	.023	33	view →
UCEC	DFS	Tertile	All	0.782	0.860	.013	32	view →
ESCA	OS	Median	IV	0.222	0.698	.006	30	view →
LIHC	DFS	Tertile	All	0.152	0.311	.013	27	view →
KIRC	DFS	Tertile	All	0.498	0.662	.003	24	view →
KICH	OS	Tertile	All	0.537	0.916	.006	21	view →
LUAD	DFS	Median	IV	0.666	0.978	.015	12	view →
DLBC	OS	Quartile	III,IV	0.610	1.000	.008	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

Exploration

Same gene, other analysis: ASIC4-AS1 tumor-vs-normal RNA expression · all ASIC4-AS1 data types