Across TCGA pan-cancer cohorts, ASIC4-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ASIC4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ASIC4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ASIC4-AS1 is over-expressed in tumor, although a few such as UCEC and BLCA show the opposite, repressed pattern.

HNSC, LUAD, and UCEC are the cancer types where ASIC4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASIC4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.082	.012	8	view →
LUAD	All	All	+0.121	<.001	6	view →
UCEC	All	All	−0.245	.004	4	view →
BLCA	Female	All	−0.211	.028	3	view →
CHOL	All	All	+0.269	.008	2	view →
PRAD	All	All	−0.242	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: ASIC4-AS1 RNA expression & survival · all ASIC4-AS1 data types