ASIC2

Across TCGA patient cohorts, ASIC2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASIC2-associated genes across cancer lineages are p62 Lck ligand, Rab11, and FOXO3a_pS318_S321. Each is linked with ASIC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASIC2-to-partner and partner-to-ASIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ASIC2-low versus ASIC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC2→partner) and Y-score (partner→ASIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.352	+2.232	.002	.005	3	3
LUSC	Rab11 →	-0.146	-2.990	.030	.036	3	2
UCEC	FOXO3a_pS318_S321 →	-0.150	-2.392	<.001	<.001	3	2
UCEC	Rictor_pT1135 →	-0.090	-1.584	.012	.034	3	2
UCEC	ASNS →	+0.256	+2.321	.045	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.643	+1.604	.002	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

p62 Lck ligand by ASIC2 expression — UCEC

Explore this box plot interactively →