ASIC1

Across TCGA cell cohorts, ASIC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,182 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ASIC1-associated GO terms across cancer lineages are Heme A biosynthetic process, Purine nucleoside triphosphate metabolic process, and Base-excision repair, gap-filling. Each is linked with ASIC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ASIC1-to-partner and partner-to-ASIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heme A biosynthetic process grouped by ASIC1-low versus ASIC1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC1→partner) and Y-score (partner→ASIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Heme A biosynthetic process →	+0.085	+1.118	<.001	.001	3	10
BONE	Purine nucleoside triphosphate metabolic process →	+0.100	+1.229	.002	.005	3	10
LARGE_INTESTINE	Base-excision repair, gap-filling →	+0.118	+1.244	<.001	.003	3	10
LUNG_SCLC	Purine nucleotide biosynthetic process →	+0.076	+2.546	<.001	<.001	3	10
OVARY	Regulation of endothelial tube morphogenesis →	-1.234	-1.405	<.001	<.001	3	9
OVARY	Tetrapyrrole biosynthetic process →	+0.074	+0.996	.002	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,182 associations by consensus.

Heme A biosynthetic process by ASIC1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →