ASIC1

Across TCGA pan-cancer cohorts, ASIC1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ASIC1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ASIC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ASIC1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

COAD, LUAD, and LUSC are the cancer types where ASIC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASIC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+2.405	<.001	12	view →
LUAD	Female	All	+0.766	<.001	9	view →
LUSC	Female	II,III,IV	+1.715	<.001	8	view →
KIRC	Male	II,III,IV	−0.452	<.001	8	view →
LIHC	All	II,III,IV	+1.022	<.001	7	view →
KICH	Male	II,III,IV	+1.445	.009	4	view →
BRCA	Female	All	−0.352	.002	4	view →
READ	All	III,IV	+2.405	.002	3	view →
CHOL	All	All	+1.565	<.001	2	view →
BLCA	Male	IV	−1.535	<.001	2	view →
PRAD	All	All	+0.550	<.001	2	view →
THCA	Female	III,IV	+0.541	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ASIC1–COAD

Open the COAD breakdown →