ASIC1

Across TCGA cell cohorts, ASIC1 mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASIC1-associated genes across cancer lineages are OC90, CBY1, and SGSM3. Each is linked with ASIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASIC1-to-partner and partner-to-ASIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OC90 grouped by ASIC1-low versus ASIC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC1→partner) and Y-score (partner→ASIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.580	+2.451	.002	.009	3	1
LARGE_INTESTINE	SGSM3 →	+0.717	+3.307	.001	.003	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.645	+2.451	<.001	.009	3	1
LARGE_INTESTINE	DDHD1 →	+0.737	+3.502	.002	.001	3	1
LARGE_INTESTINE	METTL4 →	+0.700	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

OC90 by ASIC1 expression — BLOOD_Leukemia

Explore this box plot interactively →