ASH2L

Across TCGA cell cohorts, ASH2L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,097 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ASH2L-associated GO terms across cancer lineages are Negative regulation of sister chromatid cohesion, Microtubule cytoskeleton organization involved in mitosis, and Regulation of chromosome segregation. Each is linked with ASH2L in more than 14 cancer types. Because this analysis shows association rather than direction, both ASH2L-to-partner and partner-to-ASH2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of sister chromatid cohesion grouped by ASH2L-low versus ASH2L-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASH2L→partner) and Y-score (partner→ASH2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of sister chromatid cohesion →	+0.162	+1.251	.001	.001	3	15
LARGE_INTESTINE	Microtubule cytoskeleton organization involved in mitosis →	+0.088	+0.869	<.001	<.001	3	14
BLOOD_Lymphoma	Regulation of chromosome segregation →	+0.108	+1.130	<.001	<.001	3	13
BREAST	Interkinetic nuclear migration →	+0.100	+0.962	<.001	.001	3	11
BREAST	Regulation of sister chromatid segregation →	+0.098	+1.142	.001	<.001	2	12
BREAST	Mitotic spindle organization →	+0.059	+1.047	.007	.007	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,097 associations by consensus.

Negative regulation of sister chromatid cohesion by ASH2L expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →