ASH2L

Across TCGA cell cohorts, ASH2L mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ASH2L-associated genes across cancer lineages are C10orf53, DEFB123, and KRTAP13-4. Each is linked with ASH2L in more than 1 cancer types. Because this analysis shows association rather than direction, both ASH2L-to-partner and partner-to-ASH2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by ASH2L-low versus ASH2L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASH2L→partner) and Y-score (partner→ASH2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C10orf53 →	+0.015	+4.217	<.001	.001	3	1
LUNG_SCLC	DEFB123 →	+0.062	+4.058	<.001	.007	3	1
LUNG_SCLC	KRTAP13-4 →	+0.024	+4.058	<.001	.007	3	1
BLOOD_Lymphoma	CYP7A1 →	+0.023	+4.191	<.001	.007	3	1
STOMACH	KRTAP10-7 →	+0.020	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C10orf53 by ASH2L expression — LARGE_INTESTINE

Explore this box plot interactively →