ASF1A

Across TCGA pan-cancer cohorts, ASF1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ASF1A data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ASF1A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ASF1A expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

HNSC, GBM, and LUAD are the cancer types where ASF1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.226	1.000	.008	34	view →
GBM	OS	Quartile	All	0.784	0.410	.003	19	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	18	view →
LSCC	OS	Median	II,III,IV	0.854	0.621	.034	5	view →
CCRCC	DFS	Median	III,IV	0.750	0.466	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ASF1A–HNSC (OS)

Open the HNSC breakdown →