ASF1A

Across TCGA pan-cancer cohorts, ASF1A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ASF1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ASF1A RNA is repressed in tumor relative to normal tissue. In most cancer types ASF1A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where ASF1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASF1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.703	<.001	11	view →
KICH	Male	All	−1.463	<.001	10	view →
HNSC	Male	IV	+0.966	<.001	10	view →
LIHC	Female	III,IV	+0.904	<.001	9	view →
THCA	All	All	−0.241	.007	6	view →
CHOL	All	All	+1.343	.002	4	view →
BRCA	All	II,III,IV	+0.228	.001	4	view →
LUAD	Female	II,III,IV	−0.462	.017	3	view →
PAAD	Female	All	−0.544	.014	2	view →
KIRP	Male	All	−0.481	.003	2	view →
STAD	All	II,III,IV	+0.455	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ASF1A–KIRC

Open the KIRC breakdown →