ASF1A

Across TCGA patient cohorts, ASF1A mutation is significantly associated with the RNA expression of many other genes, with 1,129 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASF1A-associated genes across cancer lineages are MARK2P5, RNU6-1101P, and RNA5SP519. Each is linked with ASF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ASF1A-to-partner and partner-to-ASF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MARK2P5 grouped by ASF1A-low versus ASF1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASF1A→partner) and Y-score (partner→ASF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MARK2P5 →	+0.041	+2.957	.001	.009	3	2
UCEC	RNU6-1101P →	+0.372	+2.813	<.001	.005	3	2
UCEC	RNA5SP519 →	+0.348	+2.813	.008	.005	3	2
UCEC	LIN7C →	+0.714	+3.606	.002	.001	3	1
UCEC	PGAP2 →	+0.467	+3.595	.007	.001	3	1
UCEC	TIRAP →	+0.565	+3.617	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,129 associations by consensus.

MARK2P5 by ASF1A expression — UCEC

Explore this box plot interactively →