ASCL5

Across TCGA cell cohorts, ASCL5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASCL5-associated genes across cancer lineages are MAGEB4, BPY2, and BPY2B. Each is linked with ASCL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCL5-to-partner and partner-to-ASCL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by ASCL5-low versus ASCL5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL5→partner) and Y-score (partner→ASCL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	BPY2 →	+0.022	+5.022	<.001	.002	3	1
LARGE_INTESTINE	BPY2B →	+0.022	+5.022	<.001	.002	3	1
LARGE_INTESTINE	BPY2C →	+0.022	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CCDC195 →	+0.068	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MAGEB4 by ASCL5 expression — LARGE_INTESTINE

Explore this box plot interactively →